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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
Main Interactions:
MedicationFinancial Or Format (Inclusive of the 3)
Interaction
Higher dosage
Lower dosage
Comparative Analysis of Cialis (Tadalafil) vs. Other Medications: Time to Dizziness, Fainting, and Orthostates

Cialis, like all medications, can cause side effects and interact with other medications you take, so it's important to use the most appropriate medication for your needs (or you can always split the medication). It's possible to have adverse interactions with Cialis or other medications, which can make the best decisions for your treatment. Here are the 3 drugs to time Cialis:

  1. Tadalafil
  2. Cialis
  3. Other medications to use with Cialis

Cialis has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.

Common side effects reported from Cialis use include:

  • Headache
  • Indigestion
  • Heartburn
  • Upset stomach
  • Gas
  • Nausea
  • Flushing

More severe side effects include:

  • Painful erections or erections that last longer than 4 hours
  • Sudden loss of vision
  • Sudden loss of hearing
  • Ringing in the ears
  • Chest pain
  • Shortness of breath
  • Painful urination
  • Increased urination frequency
  • Fainting
  • Dizziness
  • Skin rash
  • Hives
  • Facial swelling

If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.

As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Cialis. Cialis can interact with bodily substances, causing potentially serious adverse reactions.

Specifically, you should inform your health care provider of any alpha-blocker, antifungal, HIV protease inhibitor, or high blood pressure medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.

In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.

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As with all prescription medications, let your doctor know if you have any and all of the following:

  • All of the above medications, including Cialis.
  • Liver disease
  • Heart disease
  • Heart attack
  • Stroke
  • Stiffness
  • Thyroid disease

Do not use Cialis if you are pregnant or plan to become pregnant. If you faint (e.g.,erection less than 6 hours old, no pulse, vomiting, or diarrhea), seek immediate medical assistance, as some medications can cause a rare but serious drop in blood pressure.

If you have ever had an erection that lasted more than 4 hours, this medication could be harmful. If you experience an erection that lasts more than 6 hours, ringworm, exposure to ultraviolet light, or an erection that feels firm or firm enough to have sex, seek medical attention immediately.

How can I get more information on Cialis?

This product may cause health-related quality of life issues. For questions about how to obtain more information, consult your doctor.

What is Cialis used for?

Cialis is used to treat erectile dysfunction in men. It works by increasing blood flow to the penis.

Cialis can also treat pulmonary arterial hypertension. It works by relaxing the muscles in the blood vessels that supply the lungs, giving more blood to the lungs. This allows blood to flow more freely in the lungs.

Cialis can cause side effects, including:

  • Muscle pain

As with any medication, start within the first 5 days of taking Cialis.

Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
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    Erectile Dysfunction

    If you suffer from erection problems, it is very important that you have a correct erection medication. These medications are known as PDE-5 inhibitors, which means they block the action of PDE-5, which in turn allows your body to relax and give you a stronger and longer lasting erection.

    If you have erectile dysfunction, there is no reason to avoid using it.

    Viagra

    If you have a penis and have a problem with it, you should avoid taking Viagra.

    Viagra is one of the most effective PDE-5 inhibitors, however, it can take a longer time to work. So, it is important that you do not take it for longer than the recommended amount of time. If you are taking it for a longer time, you should talk to your doctor about whether you should stop taking it.

    If you are taking Viagra, you should be able to get an erection for a long time. You should tell your doctor if you have a problem with the erection.

    Proitimate Medications

    The PDE-5 inhibitors are used for the treatment of erectile dysfunction and they work by relaxing the muscles of the penis. When this happens, the muscles become relaxed and blood flow to the penis gets better. This causes a natural erection.

    Viagra is only for men and is not approved by the FDA. Viagra is used for men only and does not work for women. Women who are having a female sexual dysfunction problem should not use Viagra.

    Cialis

    Cialis is a PDE-5 inhibitor and it works by relaxing the muscles of the penis and allowing blood to flow into the penis.

    If you have erectile dysfunction, you should know that there is no reason to take any drug without a doctor’s prescription. There are certain drugs that are effective for the treatment of erectile dysfunction. They are known as PDE-5 inhibitors.

    When a person starts taking Viagra, they will not need to take them for long. They will start to feel the effects of Viagra and they will not have an erection.

    Dapoxetine

    Dapoxetine is a PDE-5 inhibitor. It works by relaxing the muscles of the penis and allowing blood to flow into the penis.

    It is also important that you do not take it for longer than recommended. If you are taking it for longer than a certain length of time, you should talk to your doctor about whether you should stop using it.

    Generic Viagra

    Generic Viagra is one of the most effective PDE-5 inhibitors, however, it can take a longer time to work. This drug is also used to treat erectile dysfunction and is available in the form of a tablet or as a gel. The drug is only available with a prescription. It is only available on the condition that the person who has taken the drug is also taking it.

    If you have erectile dysfunction, you should tell your doctor about this drug before taking Viagra. This is because if you have been prescribed the medication, you should know that it is not for the treatment of erectile dysfunction.

    Cialis is a PDE-5 inhibitor.

    If you have erectile dysfunction, you should tell your doctor before taking Cialis. This is because if you have been prescribed Cialis, you should know that it is not for the treatment of erectile dysfunction.

    If you have a problem with the erection, you should tell your doctor about this drug before taking Cialis.

    Levitra

    Levitra is a PDE-5 inhibitor.

    If you have erectile dysfunction, you should tell your doctor about this drug before taking Levitra.